The Magicians: Are certain people predisposed to becoming niffins?

Spoilers for season 1 of The Magicians (and if you know what happens later in the books…you know where this is headed).

The idea that certain people can tap into an incredible amount of power but at an incredible cost is interesting story material. You can play with motivations. What circumstances would push a person to take on that much power, knowing they will probably die?

TV Tropes calls it the Deadly Upgrade. In The Magicians, a deadly upgrade results in a niffin, a malicious spirit of magic.

Do you know what a niffin is? It’s when too much runs through you. It consumes you. Only the magic is left. But you’re not you anymore, you’re lost.

– 1×03 “Consequences of Advanced Spellcasting”

What if most magicians have something like a gag reflex when they get up to high levels of power? Some kind of hard-wired reaction that makes them back down so that they don’t turn into niffins. What if certain magicians can ignore that reflex and keep using a dangerous amount of power, even though it’s harmful to them?